(-: , : ; ) () ® ( : ) () - 4 , - () 7 1 ( 12 ).
III ( 311)2 II ( 232)3 , . 311 , , 4 12 .2 232 , , ( 2 12 ).3
® , , , AMPA-, , , AMPA- .1
70 , , , . ® ( - ) 4 , 12 . (CHMP) (EMA) - 4 7 . 300 000 .
, , . , , ®. , , .
3112
311 (, , , ) III , 180 4 12 . , 11 12 , . 2 16 . . , 12 . ( 10% ) , , , , , , .
2323
232 (, ) 50 ( 2 12 ). , , , . , , 0,015 / 0,18 /; 11 (41 ) . ( 10% ) 232 , , , , , , .
, 60% . , , ( - ). .
1 5, 3,4 6, 6 60 . 30% 4, . , . , , .
:
2. A. Fogarasi et al. Open-label study to investigate the safety and efficacy of adjunctive perampanel in pediatric patients (4 to <12 years) with inadequately controlled focal seizures or generalized tonic-clonic seizures Epilepsia. 2020 Jan;61(1):125-137.
3. J. Ben Renfroe et al. Adjunctive Perampanel Oral Suspension in Pediatric Patients From ≥2 to <12 Years of Age With Epilepsy: Pharmacokinetics, Safety, Tolerability, and Efficacy J Child Neurol. 2019 Apr;34(5):284-294
4. "The Epilepsies and Seizures: Hope Through Research. What are the epilepsies? National Institute of Neurological Disorders and Stroke, accessed May 24, 2016, http://www.ninds.nih.gov/disorders/epilepsy/detail_epilepsy.htm#230253109 : 2020
5. Japanese Declaration on Epilepsy September 30, 2013. The Japan Epilepsy Society Japan Epilepsy Association.
6. Epilepsy Prevalence in the United States.
: https://www.cdc.gov/epilepsy/data/index.html#:~:text=Epilepsy%20Prevalence%20in%20the%20United%20States &text=This%20is%20about%203.4%20million,in%20the%20data%20table%20below. : , 2020